Quartermain D, Nuygen T, Sheu J, Herting R L
Department of Neurology, New York University Medical Center, NY 10016.
Pharmacol Biochem Behav. 1991 May;39(1):31-5. doi: 10.1016/0091-3057(91)90393-g.
The objective of this study was to evaluate the effectiveness of milacemide as a memory-enhancing drug in mice. Experiment 1 showed that forgetting of active avoidance learning produced by a 14-day training to test delay could be alleviated by milacemide (10 mg/kg) administered before the retention test. Experiment 2 demonstrated that the same dose of milacemide could also attenuate spontaneous forgetting of passive avoidance learning, thereby ruling out nonspecific effects as an explanation for the enhancement of performance following pretesting drug administration. A third experiment showed that the facilitation of retrieval induced by milacemide could be blocked by the NMDA receptor antagonist AP-7, suggesting that the effects of milacemide on memory may be mediated by NMDA receptor activation. A final experiment demonstrated that retention was improved when milacemide was administered immediately following active avoidance training, indicating that the drug can also facilitate remembering by its actions on consolidation and storage processes.
本研究的目的是评估米拉醋胺作为一种增强小鼠记忆力药物的有效性。实验1表明，在进行14天训练至测试延迟后产生的主动回避学习遗忘，可通过在记忆测试前给予米拉醋胺（10毫克/千克）得到缓解。实验2证明，相同剂量的米拉醋胺也可减弱被动回避学习的自然遗忘，从而排除了非特异性效应作为给药前测试后表现增强的解释。第三个实验表明，米拉醋胺诱导的检索促进作用可被NMDA受体拮抗剂AP - 7阻断，这表明米拉醋胺对记忆的影响可能是由NMDA受体激活介导的。最后一个实验表明，在主动回避训练后立即给予米拉醋胺时，记忆得到改善，这表明该药物还可通过其对巩固和存储过程的作用来促进记忆。
