Shalev O
Department of Medicine, Hadassah University Hospital-Mount Scopus Jerusalem, Israel.
Ren Fail. 1991;13(1):27-30. doi: 10.3109/08860229109022143.
Erythrocyte (Ca2+ + Mg2+)-ATPase activity and calcium content were determined in 15 uremic-hemodialyzed patients and 15 normal controls. A decrease in the activity of the enzyme (mean +/- SD = 65 +/- 7 vs. 79 +/- 12 mumol Pi/g Hb/h, p less than 0.001) and a parallel increase in the calcium content (17.2 +/- 6.4 vs. 5.1 +/- 4.2 mumol/L RBC, p less than 0.05) were found in the patients' erythrocytes when compared with those of the controls. It is proposed that malfunction of the calcium pump in hemodialyzed uremic patients is pathophysiologically significant in the accumulation of intracellular calcium. The increased intracellular calcium found in other tissues in uremia may be the result of the systemic malfunction of (Ca2+ + Mg2+)-ATPase in this disorder.
测定了15例接受血液透析的尿毒症患者和15例正常对照者的红细胞（Ca2+ + Mg2+）-ATP酶活性及钙含量。与对照组相比，患者红细胞中该酶活性降低（均值±标准差=65±7 vs. 79±12 μmol Pi/g Hb/h，p<0.001），钙含量平行升高（17.2±6.4 vs. 5.1±4.2 μmol/L RBC，p<0.05）。有人提出，血液透析的尿毒症患者钙泵功能异常在细胞内钙蓄积的病理生理过程中具有重要意义。尿毒症时其他组织中细胞内钙增加可能是该疾病中（Ca2+ + Mg2+）-ATP酶全身性功能异常的结果。
