DNA聚合酶对芘和BODIPY修饰的寡核苷酸的核苷酸插入和旁路合成
Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases.
作者信息
Wanninger-Weiss Claudia, Di Pasquale Francesca, Ehrenschwender Thomas, Marx Andreas, Wagenknecht Hans-Achim
机构信息
University of Regensburg, Institute for Organic Chemistry, D-93040 Regensburg, Germany.
出版信息
Chem Commun (Camb). 2008 Mar 28(12):1443-5. doi: 10.1039/b718002k. Epub 2008 Jan 29.
DOI:10.1039/b718002k
PMID:18338050
Abstract
The chromophores pyrene and bordipyrromethenylbenzene directly linked to the 5-position of uridine are tolerated and recognized as thymine derivatives by DNA polymerases in primer extension experiments.
摘要
在引物延伸实验中，与尿苷5位直接相连的发色团芘和硼二吡咯亚甲基苯可被DNA聚合酶耐受，并被识别为胸腺嘧啶衍生物。
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