Shinbori Chiko, Shirayama Yukihiko, Mitani Hideaki, Saito Motoaki, Satoh Keisuke
Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago, Japan.
Neurochem Res. 2008 Jul;33(7):1189-95. doi: 10.1007/s11064-008-9611-2. Epub 2008 Mar 13.
The aim of this study was to evaluate the effects of streptozotocin-induced type 1diabetes and a subchronic treatment with cyclohexanonic long-chain fatty alcohol, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen 1-one (tCFA15) on contents of amino acids including aspartate, glutamate, glutamine, GABA, glycine, taurine, alanine, serine, threonine, and arginine in the prefrontal cortex, hippocampus and striatum. Levels of glutamate, threonine, taurine, alanine, arginine, and the ratio of glutamate/glutamine were altered region-differently in the brain of diabetic rats. However, tCFA15 region-specifically antagonized the changes in taurine and arginine levels and the ratio of glutamate/glutamine. The alteration in glutamate/glutamine ratio may indicate that experimental models of type 1 diabetes have abnormalities of neuron-gria interaction in brain.
本研究的目的是评估链脲佐菌素诱导的1型糖尿病以及用环己烷类长链脂肪醇3-(15-羟基十五烷基)-2,4,4-三甲基-2-环己烯-1-酮（tCFA15）进行亚慢性治疗对前额叶皮质、海马体和纹状体中包括天冬氨酸、谷氨酸、谷氨酰胺、γ-氨基丁酸、甘氨酸、牛磺酸、丙氨酸、丝氨酸、苏氨酸和精氨酸在内的氨基酸含量的影响。糖尿病大鼠大脑中谷氨酸、苏氨酸、牛磺酸、丙氨酸、精氨酸的水平以及谷氨酸/谷氨酰胺的比值存在区域差异的改变。然而，tCFA15可区域特异性地拮抗牛磺酸和精氨酸水平以及谷氨酸/谷氨酰胺比值的变化。谷氨酸/谷氨酰胺比值的改变可能表明1型糖尿病实验模型存在大脑中神经元-神经胶质细胞相互作用异常。
