[委内瑞拉加拉加斯大都市区六个医疗中心的念珠菌临床分离株的分布及抗真菌药敏性（2003 - 2005年）]

[Distribution and antifungal susceptibility of Candida clinical isolations coming from six health care centers in the metropolitan area of Caracas, Venezuela (years 2003-2005)].

作者信息

Dolande Franco Maribel E, Reviákina Vera, Panizo María Mercedes, Macero Carolina, Moreno Xiomara, Calvo Alberto, Selgrad Sofía, Papatzikos Juana, Vergara Vivian, Mendoza María José

机构信息

Departamento de Micología, Instituto Nacional de Higiene Rafael Rangel, Ciudad Universitaria, Los Chaguaramos, Caracas, Venezuela.

出版信息

Rev Iberoam Micol. 2008 Mar;25(1):17-21. doi: 10.1016/s1130-1406(08)70005-6.

DOI:10.1016/s1130-1406(08)70005-6

PMID:18338922

Abstract

The aim of this study was to investigate the frequency and antifungal susceptibility of Candida clinical isolations coming from patients with candidiasis in six health care centers of Caracas, Venezuela metropolitan area. The laboratory reports were retrospectively revised from January 2003 through August 2005. The isolated yeasts identification was carried out by conventional methods and antifungal susceptibility was evaluated by ATB-fungus (bioMérieux, France) and Etest (AB Biodisk, Solna, Sweden). One thousand nine hundred seventy seven (1.977) yeasts were studied and their susceptibility testing were carried out only in 1,414 of them. C. albicans was the most isolated yeast (46.7%) and none-albicans Candida-species represented more than half of the isolations (53.4%). All the isolated yeasts evaluated presented CMIs<1 microg/ml to anfotericina B and showed variable susceptibility percentages to fluconazole (91.5%), itraconazole (80%) and voriconazole (98.6%).

摘要

本研究旨在调查委内瑞拉首都加拉加斯六个医疗中心念珠菌病患者临床分离出的念珠菌的频率及抗真菌药敏情况。对2003年1月至2005年8月的实验室报告进行回顾性分析。分离出的酵母通过传统方法进行鉴定，抗真菌药敏通过ATB-真菌（法国生物梅里埃公司）和Etest（瑞典索尔纳AB生物盘公司）进行评估。共研究了1977株酵母，仅对其中1414株进行了药敏试验。白色念珠菌是分离出最多的酵母（46.7%），非白色念珠菌占分离株的一半以上（53.4%）。所有评估的分离酵母对两性霉素B的最低抑菌浓度（CMIs）<1微克/毫升，对氟康唑（91.5%）、伊曲康唑（80%）和伏立康唑（98.6%）的药敏率各不相同。