Massé P G, Tranchant C C, Jougleux J L, Coburn S P, Cole D E
School of Food Science and Nutrition, Université de Moncton, New Brunswick, Canada.
J Hum Nutr Diet. 2008 Apr;21(2):117-28. doi: 10.1111/j.1365-277X.2008.00852.x.
Recent research suggests that cardiovascular disease (CVD) and bone loss are functionally interwoven. This study examined the concomitant effects of a nutritional treatment of osteopaenia on CVD-risk factors.
A 1-year placebo-controlled trial was conducted on middle-aged women with normal (group A) or low (groups B and C) bone mineral density. Subjects (n = 20 per group) took daily either a placebo, calcium carbonate alone or combined to a vitamin (C and B(6))-proline capsule, respectively. Urinary pyridoxic acid (used to assess treatment compliance), plasma homocysteine, serum lipids and lipoproteins were measured before and after nutritional intervention.
Groups were comparable at baseline in most parameters of interest. No changes occurred in groups A and B. The 4%, 7% and 25% reductions of total cholesterol, LDL and triglycerides, and 14% elevation of HDL were all significant in group C. A trend toward reduction was observed for homocysteine in this group.
Vitamins C (500 mg) and B(6) (75 mg) combined with proline had consistent beneficial effects on CVD-risk factors, whereas calcium alone did not. This study also underlined the importance of considering vitamin B(6) status as a potential CVD risk factor.
近期研究表明，心血管疾病（CVD）与骨质流失在功能上相互关联。本研究探讨了骨质疏松症营养治疗对心血管疾病危险因素的伴随影响。
对骨密度正常（A组）或偏低（B组和C组）的中年女性进行了一项为期1年的安慰剂对照试验。受试者（每组20人）分别每日服用安慰剂、单独的碳酸钙或与维生素（C和B6）-脯氨酸胶囊联用。在营养干预前后测量尿中吡哆酸（用于评估治疗依从性）、血浆同型半胱氨酸、血清脂质和脂蛋白。
在大多数感兴趣的参数方面，各组在基线时具有可比性。A组和B组未发生变化。C组总胆固醇、低密度脂蛋白和甘油三酯分别降低4%、7%和25%，高密度脂蛋白升高14%，均具有显著性。该组同型半胱氨酸有降低趋势。
维生素C（500毫克）和B6（75毫克）与脯氨酸联用对心血管疾病危险因素有持续的有益作用，而单独使用钙则无此作用。本研究还强调了将维生素B6状态视为潜在心血管疾病危险因素的重要性。
