大鼠体内叶酸水平的降低：中枢神经系统与外周神经系统在叶酸耗竭方面的差异。

Reduction of folate levels in the rat: Difference in depletion between the central and the peripheral nervous system.

Fehling C, Jägerstad M, Lindstrand K, Elmquist D

Z Ernahrungswiss. 1976 Mar;15(1):1-8. doi: 10.1007/BF02283132.

Abstract

Rats were deprived of dietary folate for 12 and 9.5 months in two experiments; one with and one without succinylsulfathiazole added to the diet. Folate levels decreased faster in the former experiment and the final blood values were lower. Tissue folate was examined in the latter experiment only. 2. The animals were repeatedly examined with neurological tests and compared with a control group supplemented with folic acid. Every test proved normal. Measurement of motor nerve conduction velocities after 12 months in the experiment where succinylsulfathiazole was given revealed lower velocities in the non-supplemented group. There was no difference between the groups in the experiment without succinylsulfathiazole. 3. In the latter experiment brain folate was reduced by only 16% in the non-supplemented animals compared with the controls, whereas whole blood folate fell by 60%, liver folate by 50% and sciatic nerve folate by 59%. 4. The central nervous system is resistant to systemic folate depletion, whereas the peripheral nerves are depleted to the same degree as the extra-neural tissues.

摘要

在两项实验中，大鼠被剥夺膳食叶酸12个月和9.5个月；一项实验在饮食中添加了琥珀酰磺胺噻唑，另一项未添加。在前一项实验中叶酸水平下降得更快，最终血液值更低。仅在后一项实验中检测了组织叶酸。2. 对动物进行多次神经学测试，并与补充叶酸的对照组进行比较。每项测试结果均正常。在给予琥珀酰磺胺噻唑的实验中，12个月后测量运动神经传导速度，结果显示未补充组的速度较低。在没有琥珀酰磺胺噻唑的实验中，两组之间没有差异。3. 在后一项实验中，与对照组相比，未补充叶酸的动物大脑叶酸仅减少了16%，而全血叶酸下降了60%，肝脏叶酸下降了50%，坐骨神经叶酸下降了59%。4. 中枢神经系统对全身性叶酸缺乏具有抗性，而外周神经与神经外组织一样被耗尽。