聚左旋乳酸/普朗尼克P104薄膜内的客体聚集

Guest aggregation within poly(L-lactic acid)/pluronic P104 thin films.

作者信息

Steves Jordan M, Tan Loraine T, Gardella Joseph A, Hard Robert, Hicks Wesley L, Cartwright Alexander N, Koc Bahattan, Bright Frank V

机构信息

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.

出版信息

Appl Spectrosc. 2008 Mar;62(3):290-4. doi: 10.1366/000370208783759605.

DOI:10.1366/000370208783759605

PMID:18339236

Abstract

Rhodamine 6G (R6G) doped thin films composed of poly(L-lactic acid) (PLLA) and Pluronic P104 were spin cast onto glass microscope slides and characterized by ultraviolet-visible, steady-state, and time-resolved fluorescence spectroscopy. The results show that R6G aggregation within the film increases as the R6G concentration and P104 loading increases. These results suggest an approach for studying drug distributions (monomers, aggregates) within biodegradable polymer formulations.

摘要

将由聚（L-乳酸）（PLLA）和普朗尼克P104组成的罗丹明6G（R6G）掺杂薄膜旋涂在玻璃显微镜载玻片上，并通过紫外可见、稳态和时间分辨荧光光谱进行表征。结果表明，随着R6G浓度和P104负载量的增加，薄膜内R6G的聚集增加。这些结果提出了一种研究可生物降解聚合物制剂中药物分布（单体、聚集体）的方法。