Shimono T, Matsunaga S, Fukada E, Hattori T, Shikinami Y
Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan.
In Vivo. 1996 Sep-Oct;10(5):471-6.
Uniaxially drawn poly-L-lactic acid (PLLA) films with piezoelectric properties were inserted onto the periosteum of rabbit tibiae, and the effect of the films in promoting ossification was investigated. We also evaluated the optimum method for PLLA film insertion to promote ossification, by comparing three different types of PLLA films which differed from each other in terms of the direction of their molecular orientation. Furthermore, the course of ossification following the film insertion was observed histologically. Drawn PLLA films promoted ossification to a greater extent than undrawn PLLA film. The effect of drawn PLLA films in promoting ossification was greatest when a shearing stress was applied at 45 degrees to the axis of orientation. The newly formed osteoid was observed at 1 week, and matured over 6 to 8 weeks following insertion. The insertion of piezoelectric PLLA films can promote ossification through their piezoelectric effect, and this seems to be clinically applicable.
将具有压电特性的单轴拉伸聚-L-乳酸（PLLA）薄膜植入兔胫骨骨膜上，研究该薄膜在促进骨化方面的作用。我们还通过比较三种分子取向方向不同的PLLA薄膜，评估了促进骨化的PLLA薄膜最佳植入方法。此外，通过组织学观察薄膜植入后的骨化过程。拉伸后的PLLA薄膜比未拉伸的PLLA薄膜在更大程度上促进骨化。当与取向轴成45度角施加剪切应力时，拉伸后的PLLA薄膜促进骨化的效果最佳。植入后1周观察到新形成的类骨质，并在6至8周内成熟。压电PLLA薄膜的植入可通过其压电效应促进骨化，这似乎具有临床应用价值。
