中枢神经系统副肿瘤综合征
Paraneoplastic syndromes of the CNS.
作者信息
Dalmau Josep, Rosenfeld Myrna R
机构信息
Division of Neuro-oncology, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA.
出版信息
Lancet Neurol. 2008 Apr;7(4):327-40. doi: 10.1016/S1474-4422(08)70060-7.
Abstract
Major advances in the management of paraneoplastic neurologic disorders (PND) include the detection of new antineuronal antibodies, the improved characterisation of known syndromes, the discovery of new syndromes, and the use of CT and PET to reveal the associated tumours at an early stage. In addition, the definition of useful clinical criteria has facilitated the early recognition and treatment of these disorders. In this article, we review some classic concepts about PND and recent clinical and immunological developments, focusing on paraneoplastic cerebellar degeneration, opsoclonus-myoclonus, and encephalitides affecting the limbic system.
摘要
副肿瘤性神经系统疾病（PND）管理方面的重大进展包括发现新的抗神经元抗体、对已知综合征的特征描述得到改进、发现新的综合征，以及使用CT和PET在早期发现相关肿瘤。此外，实用临床标准的定义有助于这些疾病的早期识别和治疗。在本文中，我们回顾一些关于PND的经典概念以及近期的临床和免疫学进展，重点关注副肿瘤性小脑变性、眼阵挛-肌阵挛，以及影响边缘系统的脑炎。
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