Tian J R, Herdman S J, Zee D S, Folstein S E
Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD.
Acta Otolaryngol Suppl. 1991;481:333-6. doi: 10.3109/00016489109131415.
We studied postural control, using quantitative moving-platform posturography, in 20 patients with Huntington's Disease (HD) and in 20 age-matched controls. HD patients showed considerably more anterior-posterior sway than normals, even when a correction for chorea was attempted. This increase in sway was especially true when, by eliminating visual and by attenuating proprioceptive cues, patients were forced to rely primarily on vestibular cues for balance. HD patients also showed increased latencies (30-50 ms) but normal amplitude, in response to translational perturbations of the platform. HD patients showed increased amplitude of responses to rotational perturbations of the platform but a normal decrease in response on successive trials. Thus, patients with HD show a consistent pattern of abnormality on posturography suggesting a role for the basal ganglia in a number of aspects of postural control.
我们使用定量移动平台姿势描记法研究了20例亨廷顿舞蹈症（HD）患者和20名年龄匹配的对照者的姿势控制。HD患者即使尝试对舞蹈症进行校正，其前后摇摆也比正常人明显得多。当通过消除视觉和减弱本体感觉线索，迫使患者主要依靠前庭线索来保持平衡时，这种摇摆增加尤其明显。HD患者在平台平移扰动时，还表现出反应潜伏期增加（30 - 50毫秒）但振幅正常。HD患者对平台旋转扰动的反应振幅增加，但在连续试验中反应正常下降。因此，HD患者在姿势描记法上表现出一致的异常模式，提示基底神经节在姿势控制的多个方面发挥作用。
