Trotz-Williams Lise, Physick-Sheard Peter, McFarlane Heather, Pearl David L, Martin S Wayne, Peregrine Andrew S
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Ontario N1G 2W1, Canada.
Vet Parasitol. 2008 May 6;153(1-2):73-84. doi: 10.1016/j.vetpar.2008.01.016. Epub 2008 Jan 19.
Infection with the tapeworm Anoplocephala perfoliata has been found to be associated with equine colic in horses in the United Kingdom. Using a matched case-control study design, data collected from 117 pairs of horses in Ontario were examined for evidence of associations between risk of colic and A. perfoliata infection, and between seropositivity to infection and management practices. Cases were horses in southern Ontario diagnosed with colic by local veterinarians, and control horses were from the same stables as cases and were matched by age, breed and gender where possible. Infection status was defined on the basis of positive results upon coprological examination, and/or seropositivity to a 12/13 kDa A. perfoliata secretory protein. Fifty-six percent of the 234 horses were seropositive for A. perfoliata, but eggs were found in samples from only 6% of horses. Horses dependent on pasture for a large part of their diet were significantly more likely to have ELISA optical density levels above 0.600 compared to other horses (odds ratio [OR]=6.38; p=0.029). This finding identified exposure to pasture as an important source of A. perfoliata infection in the horses used in the study. In a subset of 46 pairs of horses for which control horses had no known history of colic, a statistically significant negative association was found between the risk of colic and optical density (OD) levels >0.200-0.600, relative to OD levels < or = 0.090 (OR=0.08; p=0.017). There was no other statistical evidence of an association between the risk of colic and A. perfoliata infection.
在英国，已发现感染叶状裸头绦虫与马的结肠绞痛有关。采用配对病例对照研究设计，对安大略省117对马匹收集的数据进行了检查，以寻找结肠绞痛风险与叶状裸头绦虫感染之间以及感染血清阳性与管理措施之间存在关联的证据。病例为安大略省南部被当地兽医诊断为结肠绞痛的马匹，对照马与病例来自同一马厩，并尽可能按年龄、品种和性别进行配对。感染状况根据粪便学检查结果呈阳性和/或对12/13 kDa叶状裸头绦虫分泌蛋白呈血清阳性来定义。234匹马中有56%对叶状裸头绦虫呈血清阳性，但仅在6%的马的样本中发现了虫卵。与其他马匹相比，大部分饮食依赖牧场的马匹ELISA光密度水平显著更有可能高于0.600（比值比[OR]=6.38；p=0.029）。这一发现确定接触牧场是该研究中马匹感染叶状裸头绦虫的一个重要来源。在46对对照马无已知结肠绞痛病史的马匹子集中，发现结肠绞痛风险与光密度（OD）水平>0.200 - 0.600之间相对于OD水平<或 = 0.090存在统计学上显著的负相关（OR=0.08；p=0.017）。没有其他统计证据表明结肠绞痛风险与叶状裸头绦虫感染之间存在关联。
