Carballo Juan J, Akamnonu Chibuikem P, Oquendo Maria A
New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Arch Suicide Res. 2008;12(2):93-110. doi: 10.1080/13811110701857004.
Suicide is among the top ten leading causes of death in individuals of all ages. An explanatory model for suicidal behavior that links clinical and psychological risk factors or endophenotypes, to the underlying neurobiological abnormalities associated with suicidal behavior may enhance prediction, help identify treatment options and have heuristic value. Our explanatory model proposes that developmental factors that are biological (genetics) and psychological or clinical (early childhood adversity) may have causal relevance to the disturbances found in subjects with suicidal behavior. In this way, our model integrates findings from several perspectives in suicidology and attempts to explain the relationship between various neurobiological, genetic, and clinical observations in suicide research, offering a comprehensive hypothesis to facilitate understanding of this complex outcome.
自杀是各年龄段人群的十大主要死因之一。一种将临床和心理风险因素或内表型与自杀行为相关的潜在神经生物学异常联系起来的自杀行为解释模型，可能会提高预测能力，有助于确定治疗方案，并具有启发价值。我们的解释模型提出，生物学（遗传学）以及心理或临床（童年早期逆境）方面的发育因素，可能与自杀行为受试者中发现的紊乱存在因果关联。通过这种方式，我们的模型整合了自杀学多个视角的研究结果，并试图解释自杀研究中各种神经生物学、遗传学和临床观察结果之间的关系，提供一个全面的假设，以促进对这一复杂结果的理解。
