自杀行为的神经生物学。生物学与临床发现的整合。
Neurobiology of suicidal behavior. An integration of biological and clinical findings.
作者信息
Carballo Juan J, Akamnonu Chibuikem P, Oquendo Maria A
机构信息
New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
出版信息
Arch Suicide Res. 2008;12(2):93-110. doi: 10.1080/13811110701857004.
Abstract
Suicide is among the top ten leading causes of death in individuals of all ages. An explanatory model for suicidal behavior that links clinical and psychological risk factors or endophenotypes, to the underlying neurobiological abnormalities associated with suicidal behavior may enhance prediction, help identify treatment options and have heuristic value. Our explanatory model proposes that developmental factors that are biological (genetics) and psychological or clinical (early childhood adversity) may have causal relevance to the disturbances found in subjects with suicidal behavior. In this way, our model integrates findings from several perspectives in suicidology and attempts to explain the relationship between various neurobiological, genetic, and clinical observations in suicide research, offering a comprehensive hypothesis to facilitate understanding of this complex outcome.
摘要
自杀是各年龄段人群的十大主要死因之一。一种将临床和心理风险因素或内表型与自杀行为相关的潜在神经生物学异常联系起来的自杀行为解释模型，可能会提高预测能力，有助于确定治疗方案，并具有启发价值。我们的解释模型提出，生物学（遗传学）以及心理或临床（童年早期逆境）方面的发育因素，可能与自杀行为受试者中发现的紊乱存在因果关联。通过这种方式，我们的模型整合了自杀学多个视角的研究结果，并试图解释自杀研究中各种神经生物学、遗传学和临床观察结果之间的关系，提供一个全面的假设，以促进对这一复杂结果的理解。
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1
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Psychiatry Res. 2006 Dec 1;148(2-3):195-203. doi: 10.1016/j.pscychresns.2006.06.001. Epub 2006 Nov 7.
2
Self-reported and neuropsychological measures of impulsivity in pathological gambling.病理性赌博中冲动性的自我报告和神经心理学测量
J Int Neuropsychol Soc. 2006 Nov;12(6):907-12. doi: 10.1017/S1355617706061091.
3
Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.从抑郁症中康复的心境正常、未服用药物的患者5-HT(2A)受体结合增加：一项使用[(11)C]MDL 100,907的正电子发射研究。
Am J Psychiatry. 2006 Sep;163(9):1580-7. doi: 10.1176/ajp.2006.163.9.1580.
4
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide.人背侧和中缝核中神经元色氨酸羟化酶mRNA表达：重度抑郁症与自杀
Neuropsychopharmacology. 2006 Apr;31(4):814-24. doi: 10.1038/sj.npp.1300897.
5
Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide.较高的死后前额叶5-羟色胺2A受体结合与自杀中的终生攻击性相关。
Biol Psychiatry. 2006 Feb 1;59(3):235-43. doi: 10.1016/j.biopsych.2005.06.037. Epub 2005 Sep 2.
6
Correlates of trait impulsiveness in performance measures and neuropsychological tests.绩效测量和神经心理学测试中特质冲动性的相关因素。
Psychiatry Res. 2005 Jun 30;135(3):191-201. doi: 10.1016/j.psychres.2005.03.006.
7
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8
Stress models of depression: forming genetically vulnerable strains.抑郁症的应激模型：构建基因易感性品系。
Neurosci Biobehav Rev. 2005;29(4-5):799-804. doi: 10.1016/j.neubiorev.2005.03.019.
9
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10
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