Roy Alec, Sarchiopone Marco, Carli Vladimir
Psychiatry Service, New Jersey VA Healthcare System, East Orange, NJ 07018-1095, USA.
J Psychiatr Pract. 2009 Jul;15(4):282-8. doi: 10.1097/01.pra.0000358314.88931.b5.
Studies have increasingly shown that gene-environment interactions are important in psychiatry. Suicidal behavior is a major public health problem. Suicide is generally considered to be a multi-determined act involving various areas of proximal and distal risk. Genetic risk factors are estimated to account for approximately 30% to 40% of the variance in suicidal behavior. In this article, the authors review relevant studies concerning the interaction between the serotonin transporter gene and environmental variables as a model of gene-environment interactions that may have an impact on suicidal behavior. The findings reviewed here suggest that there may be meaningful interactions between distal and proximal suicide risk factors that may amplify the risk of suicidal behavior. Future studies of suicidal behavior should examine both genetic and environmental variables and examine for gene-environment interactions.
研究越来越多地表明，基因 - 环境相互作用在精神病学中很重要。自杀行为是一个重大的公共卫生问题。自杀通常被认为是一种由多种因素决定的行为，涉及近端和远端风险的各个方面。据估计，遗传风险因素约占自杀行为变异的30%至40%。在本文中，作者回顾了有关血清素转运体基因与环境变量之间相互作用的相关研究，以此作为可能影响自杀行为的基因 - 环境相互作用模型。此处回顾的研究结果表明，远端和近端自杀风险因素之间可能存在有意义的相互作用，这可能会放大自杀行为的风险。未来关于自杀行为的研究应同时考察遗传和环境变量，并研究基因 - 环境相互作用。
