Arin Letamendia Antonio, Borda Celaya Fernando, Burusco Paternain M Jesús, Prieto Martínez Carlos, Martínez Echeverría Ana, Elizalde Apestegui Inmaculada, Laiglesia Izquierdo Matilde, Macias Mendizábal Elena, Tamburri Moso Paolo, Sánchez Valverde Félix
Servicio de Aparato Digestivo, Hospital de Navarra, Pamplona, Navarra, Spain.
Gastroenterol Hepatol. 2008 Mar;31(3):111-6. doi: 10.1157/13116497.
As reflected in the European Collaborative Study on Inflammatory Bowel Disease (1991-1993), differences between northern and southern European countries in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) show a tendency to decrease. No data are available on the current incidence of these diseases in Navarre (northern Spain).
To determine the present incidence of inflammatory bowel disease (IBD) in Navarra.
A prospective, population-based study was performed to determine the incidence of IBD in Navarra between 2001 and 2003. Total population: 569,628 inhabitants (284,620 males). All cases of IBD diagnosed in any public or private hospital in Navarre were included in the study. Crude rates and age- and sex-specific rates adjusted to the European standard population were calculated.
A total of 288 cases were diagnosed (UC 176, CD 102, indeterminate colitis 10). Crude rates of UC, CD and indeterminate colitis were 10.29, 5.96 and 0.58 cases/100,000 inhabitants/year respectively (the population aged 0-14 years of age was included). Specific rates were 9.57 (95% CI, 7.27-12.57) and 5.85 (95% CI, 3.99-8.14) cases/100,000 inhabitants/year for UC and CD, respectively.
The incidence of UC and CD in Navarra has increased in the last decade, with rates close to those of northern European countries and higher than those recently published in Spanish prospective studies.
欧洲炎症性肠病协作研究（1991 - 1993年）显示，北欧和南欧国家在溃疡性结肠炎（UC）和克罗恩病（CD）发病率上的差异呈减小趋势。目前尚无关于纳瓦拉（西班牙北部）这些疾病发病率的相关数据。
确定纳瓦拉地区炎症性肠病（IBD）的当前发病率。
开展了一项基于人群的前瞻性研究，以确定2001年至2003年纳瓦拉地区IBD的发病率。总人口为569,628名居民（男性284,620名）。纳瓦拉地区任何公立或私立医院诊断出的所有IBD病例均纳入本研究。计算了粗发病率以及根据欧洲标准人群调整后的年龄和性别特异性发病率。
共诊断出288例病例（UC 176例，CD 102例，不确定性结肠炎10例）。UC、CD和不确定性结肠炎的粗发病率分别为每10万居民/年10.29例、5.96例和0.58例（纳入了0 - 14岁年龄组人群）。UC和CD的特异性发病率分别为每10万居民/年9.57例（95%可信区间，7.27 - 12.57）和5.85例（95%可信区间，3.99 - 8.14）。
在过去十年中，纳瓦拉地区UC和CD的发病率有所上升，发病率接近北欧国家，且高于西班牙近期前瞻性研究中公布的发病率。
