Constenla D, Ortega-Barría E, Rheingans R D, Antil L, Sáez-Llorens X
Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, USA.
An Pediatr (Barc). 2008 Feb;68(2):128-35. doi: 10.1157/13116227.
Rotavirus (RV) gastroenteritis (GE) causes a significant health and economic burden in Panama. The main objective of this study is to estimate the healthcare costs and the cost-effectiveness of vaccination in Panama from the societal perspective.
An economic model was constructed, using published epidemiological data, country-specific cost estimates, and vaccine efficacy data. The main outcome measures were disease burden, economic burden and the incremental cost-effectiveness ratio (US$/DALY and US$/life saved) of vaccination.
In Panama, among children during the first five years of life, it is estimated that due to RV GE, 283 per 1,000 have a clinic visit, 24 per 1,000 are hospitalized, and 0.53 per 1,000 die. For every 1,000 children born, RV infection results in US$16,463 in total costs during their first five years of life. An estimated US$862,388 may be spent annually on treatment of outpatient and hospitalized cases in Panama. Vaccination would prevent 65% of the associated deaths, 68% of hospitalizations, 69% of outpatient visits and 65% of associated DALY (Disability Adjusted Life Years). From the societal perspective, RV vaccination produces a cost-effectiveness ratio of US$487 per DALY when the price of the vaccine is US$7.50 per dose.
Vaccination can effectively reduce the disease burden and healthcare costs of RV GE in Panama.
轮状病毒（RV）肠胃炎（GE）在巴拿马造成了重大的健康和经济负担。本研究的主要目的是从社会角度估算巴拿马的医疗保健成本以及疫苗接种的成本效益。
利用已发表的流行病学数据、特定国家的成本估算和疫苗效力数据构建了一个经济模型。主要结局指标为疾病负担、经济负担以及疫苗接种的增量成本效益比（美元/伤残调整生命年和美元/挽救生命）。
在巴拿马，估计五岁以下儿童中，每1000人中有283人因RV GE就诊，每1000人中有24人住院，每1000人中有0.53人死亡。每1000名出生儿童中，RV感染在其生命的前五年导致总成本达16463美元。巴拿马每年可能花费约862388美元用于门诊和住院病例的治疗。疫苗接种可预防65%的相关死亡、68%的住院、69%的门诊就诊以及65%的相关伤残调整生命年（DALY）。从社会角度来看，当疫苗价格为每剂7.50美元时，RV疫苗接种产生的成本效益比为每DALY 487美元。
疫苗接种可有效降低巴拿马RV GE的疾病负担和医疗保健成本。
