Ting Jenny P-Y, Lovering Ruth C, Alnemri Emad S, Bertin John, Boss Jeremy M, Davis Beckley K, Flavell Richard A, Girardin Stephen E, Godzik Adam, Harton Jonathan A, Hoffman Hal M, Hugot Jean-Pierre, Inohara Naohiro, Mackenzie Alex, Maltais Lois J, Nunez Gabriel, Ogura Yasunori, Otten Luc A, Philpott Dana, Reed John C, Reith Walter, Schreiber Stefan, Steimle Viktor, Ward Peter A
Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
Immunity. 2008 Mar;28(3):285-7. doi: 10.1016/j.immuni.2008.02.005.
Iimmune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, cryopyrin/NALP3 are members of a family characterized by the presence of a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). Members of this gene family encode a protein structure similar to the NB-LRR subgroup of disease-resistance genes in plants and are involved in the sensing of pathogenic products and the regulation of cell signaling and apoptosis. Several members of this family have been associated with immunologic disorders. for instance is associated with both Crohn's disease and Blau syndrome. A variety of different names are currently used to describe this gene family, its subfamilies and individual genes, including CATERPILLER (CLR), NOD-LRR, NACHT-LRR, CARD, NALP, NOD, PAN and PYPAF, and this lack of consistency has led to a pressing need to unify the nomenclature. Consequently, we collectively propose the family designation NLR (nucleotide-binding domain and leucine-rich repeat containing) and provide unique and standardized gene designations for all family members.
免疫调节蛋白如CIITA、NAIP、IPAF、NOD1、NOD2、NALP1、冷吡啉/NALP3是一个家族的成员，其特征是存在核苷酸结合结构域（NBD）和富含亮氨酸的重复序列（LRR）。该基因家族的成员编码一种与植物抗病基因的NB-LRR亚组相似的蛋白质结构，并参与病原体产物的感知以及细胞信号传导和细胞凋亡的调节。该家族的几个成员与免疫紊乱有关。例如，它与克罗恩病和布劳综合征都有关联。目前使用了多种不同的名称来描述这个基因家族、其亚家族和单个基因，包括CATERPILLER（CLR）、NOD-LRR、NACHT-LRR、CARD、NALP、NOD、PAN和PYPAF，这种不一致性导致迫切需要统一命名法。因此，我们共同提议将该家族命名为NLR（含核苷酸结合结构域和富含亮氨酸重复序列），并为所有家族成员提供独特且标准化的基因命名。
