Kahn Richard A, Bruford Elspeth, Inoue Hiroki, Logsdon John M, Nie Zhongzhen, Premont Richard T, Randazzo Paul A, Satake Masanobu, Theibert Anne B, Zapp Maria L, Cassel Dan
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
J Cell Biol. 2008 Sep 22;182(6):1039-44. doi: 10.1083/jcb.200806041.
At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent years. A common nomenclature for these genes and proteins will facilitate discovery of biological functions and possible connections to pathogenesis. Nearly 100 researchers were contacted to generate a consensus nomenclature for human ArfGAPs. This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP domain.
2007年6月在意大利伊尔乔科举行的美国实验生物学联合会（FASEB）关于“Arf家族GTP酶”的夏季研究会议上，研究人员明显发现，近年来我们对Arf GTP酶激活蛋白（ArfGAPs）家族的了解呈指数级增长。这些基因和蛋白质的通用命名法将有助于发现其生物学功能以及与发病机制的可能联系。我们联系了近100名研究人员，以制定人类ArfGAPs的共识命名法。本文介绍了由此产生的共识命名法，并简要描述了31个人类基因的10个亚家族中的每一个，这些基因编码含有ArfGAP结构域的蛋白质。
