Nielsen Peter, Grosschedl Rudolf
Max Planck Institute of Immunobiology, Freiburg, Germany.
Immunity. 2008 Mar;28(3):295-7. doi: 10.1016/j.immuni.2008.02.007.
Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling.
免疫球蛋白重链和轻链基因以时间有序的方式进行重排。在本期中，约翰逊等人（2008年）表明，干扰素调节因子4通过激活增强子和减弱白细胞介素-7信号传导来调节轻链基因重排。
