干扰素调节因子4在早期B细胞中的多重任务作用。
Multitasking of interferon regulatory factor-4 in early B cells.
作者信息
Nielsen Peter, Grosschedl Rudolf
机构信息
Max Planck Institute of Immunobiology, Freiburg, Germany.
出版信息
Immunity. 2008 Mar;28(3):295-7. doi: 10.1016/j.immuni.2008.02.007.
PMID:18342001
Abstract
Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling.
摘要
免疫球蛋白重链和轻链基因以时间有序的方式进行重排。在本期中，约翰逊等人（2008年）表明，干扰素调节因子4通过激活增强子和减弱白细胞介素-7信号传导来调节轻链基因重排。
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