Cancro Michael P
Department of Pathology and Laboratory Medicine, 284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.
Immunity. 2008 Mar;28(3):300-1. doi: 10.1016/j.immuni.2008.02.010.
In this issue, Gardham et al. (2008) show that BAFF, a tumor necrosis factor (TNF) family member, promotes B cell survival by hindering interactions between TNF-receptor-associated factors, blocking their negative regulation of nonclassical NF-kappaB activity.
在本期中,加德姆等人(2008年)表明,肿瘤坏死因子(TNF)家族成员BAFF通过阻碍肿瘤坏死因子受体相关因子之间的相互作用,阻断它们对非经典核因子κB活性的负调控,从而促进B细胞存活。