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B淋巴细胞刺激因子（BAFF）失调在系统性红斑狼疮发病机制中起主要作用吗？

Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

作者信息

Binard Aymeric, Le Pottier Laëtitia, Saraux Alain, Devauchelle-Pensec Valérie, Pers Jacques-Olivier, Youinou Pierre

机构信息

Laboratory of Immunology, Brest University Medical School Hospital, Brest, France; Unit of Rheumatology, Brest,University Medical School Hospital, Brest, France.

出版信息

J Autoimmun. 2008 Feb-Mar;30(1-2):63-7. doi: 10.1016/j.jaut.2007.11.001. Epub 2007 Dec 21.

DOI:10.1016/j.jaut.2007.11.001
PMID:18155417
Abstract

Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited.

摘要

鉴于目前已知B淋巴细胞在系统性红斑狼疮中发挥着重要作用，肿瘤坏死因子家族的B细胞活性因子（BAFF）参与其发病机制也就不足为奇了。这种细胞因子产生过量，并与循环B细胞表面的受体结合。BAFF上调很可能会导致针对自身的B细胞异常存活，从而破坏免疫耐受。因此，已开展旨在阻断BAFF的试验。不过结果仍有待观察。

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