Simpson Kathleen Rice, James Dotti C
Labor and Delivery, St John's Mercy Medical Center, St Louis, MO, USA.
Am J Obstet Gynecol. 2008 Jul;199(1):34.e1-5. doi: 10.1016/j.ajog.2007.12.015. Epub 2008 Mar 14.
The objective of the study was to evaluate effects of oxytocin-induced hyperstimulation on fetal oxygen saturation and fetal heart rate patterns.
Uterine activity of 56 women was evaluated retrospectively for hyperstimulation lasting 30 minutes using 2 definitions: group 1: 5 or more but less than 6 contractions in 10 minutes (n = 102, 30-minute periods); group 2: 6 or more contractions in 10 minutes (n = 56, 30-minute periods). Fetal oxygen saturation and heart rate patterns during each period and the preceding 30 minutes of less than 5 contractions in 10 minutes were compared.
Hyperstimulation was associated with significant oxygen desaturation: (group 1 = 10.68 [20%] decrease from 52.14 to 41.46; P < .001); group 2 = 15.34 [29%] decrease from 52.02 to 36.68: P < .001) and significantly more nonreassuring fetal heart rate characteristics, compared with normal uterine activity.
Hyperstimulation is associated with negative effects on fetal status. The more contractions in 30 minutes, the more pronounced the effect.
本研究的目的是评估催产素诱导的子宫过度刺激对胎儿血氧饱和度和胎儿心率模式的影响。
回顾性评估了56名女性的子宫活动,使用两种定义来确定持续30分钟的子宫过度刺激:第1组:10分钟内有5次或更多但少于6次宫缩(n = 102个30分钟时段);第2组:10分钟内有6次或更多宫缩(n = 56个30分钟时段)。比较了每个时段以及之前10分钟内宫缩少于5次的30分钟期间的胎儿血氧饱和度和心率模式。
子宫过度刺激与显著的氧饱和度降低相关:(第1组:从52.14降至41.46,下降10.68[20%];P <.001);第2组:从52.02降至36.68,下降15.34[29%]:P <.001),并且与正常子宫活动相比,出现更多令人担忧的胎儿心率特征。
子宫过度刺激对胎儿状况有负面影响。30分钟内宫缩越多,影响越明显。