[Discharge of myeloperoxidase from neutrophils during bacterial sorption].

A study was made of conditions and dynamics of discharge of myeloperoxidase (MPO) from rabbit neutrophils in case of encounter with staphylococci. The discharge began not later than 9--12 minutes after the administration of Staph. aureus into the neutrophil suspension, i. e. as early as the stage of bacterial sorption, and reached the maximum by the 30th minute. The contact of neutrophils with individual bacteria was an adequate signal for the beginning of the discharge. The greatest discharge was with the ratio of 5 bacteria per one neutrophil. The discharge was retarded when this ratio reached 80: 1. A hypothesis on the "avalanche" switchingon of the system of MPO discharge: a single bacteria injection mu/ml a discharge from an individual neutrophil of MPO and cation proteins; the latter switch on discharge from several other neutrophils, without any participation of bacteria. Cation proteins intensified the MPO discharge in the concentration of the 10--20 switch on. Biolgical significance of the phenomenon of early discharge of antibacterial factors no directed to the provision of phagocytosis is discussed.