中缝正中核中的促肾上腺皮质激素释放因子参与大鼠恐惧记忆的提取。
Corticotropin releasing factor in the median raphe nucleus is involved in the retrieval of fear memory in rats.
作者信息
Ohmura Yu, Yamaguchi Taku, Izumi Takeshi, Matsumoto Machiko, Yoshioka Mitsuhiro
机构信息
Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, N15 W7 Kita-ku, Sapporo, 060-8638, Japan.
出版信息
Eur J Pharmacol. 2008 Apr 28;584(2-3):357-60. doi: 10.1016/j.ejphar.2008.02.023. Epub 2008 Mar 17.
In the present study, we examined the role of corticotropin releasing factor (CRF) in the median raphe nucleus (MRN) on fear-related behaviors in rats. We employed the contextual fear conditioning test and the elevated plus maze test as memory-dependent and -independent tasks, respectively. Human/rat CRF (10 ng) in 0.5 microl saline was injected into the MRN. Administration of CRF significantly increased memory dependent, but not independent, fear expression. These results suggest that CRF release in the MRN is involved in the retrieval of fear memory.
在本研究中，我们检测了促肾上腺皮质激素释放因子（CRF）在大鼠中缝正中核（MRN）对恐惧相关行为的作用。我们分别采用情境恐惧条件反射试验和高架十字迷宫试验作为依赖记忆和不依赖记忆的任务。将0.5微升盐水中含有的10纳克人/大鼠CRF注入中缝正中核。注射CRF显著增加了依赖记忆的恐惧表达，但未增加不依赖记忆的恐惧表达。这些结果表明，中缝正中核中CRF的释放参与了恐惧记忆的提取。
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