Laboratory of Experimental Functional Neurosurgery, Department of Neurosciences, K.U.Leuven, Leuven, Belgium.
Cogn Affect Behav Neurosci. 2011 Jun;11(2):228-44. doi: 10.3758/s13415-011-0021-6.
Animal models of psychiatric disorders are important translational tools for exploring new treatment options and gaining more insight into the disease. Thus far, there is no systematically validated animal model for generalized anxiety disorder (GAD), a severely impairing and difficult-to-treat disease. In this review, we propose contextual conditioning (CC) as an animal model for GAD. We argue that this model has sufficient face validity (there are several symptom similarities), predictive validity (it responds to clinically effective treatments), and construct validity (the underlying mechanisms are comparable). Although the refinement and validation of an animal model is a never-ending process, we want to give a concise overview of the currently available evidence. We suggest that the CC model might be a valuable preclinical tool to enhance the development of new treatment strategies and our understanding of GAD.
精神障碍动物模型是探索新治疗方法和深入了解疾病的重要转化工具。迄今为止，还没有针对广泛性焦虑障碍（GAD）这种严重致残且难以治疗的疾病进行系统验证的动物模型。在这篇综述中，我们提出情境条件作用（CC）作为 GAD 的动物模型。我们认为，该模型具有足够的表面效度（存在多种症状相似性）、预测效度（对临床有效治疗有反应）和结构效度（潜在机制相似）。尽管动物模型的细化和验证是一个永无止境的过程，但我们希望对当前可用的证据进行简明概述。我们认为 CC 模型可能是一种有价值的临床前工具，可用于增强新治疗策略的开发以及我们对 GAD 的理解。
