Motta L, Blancato G, Scornavacca G, De Luca M, Vasquez E, Gismondo M R, Lo Bue A, Chisari G
Istituto di Clinica di Gerontologia e Geriatria, Università degli Studi di Catania.
Clin Ter. 1991 Jul 15;138(1):27-35.
The possible beneficial effects and changes in the histology of the duodenojejunal and colonic mucosa brought about by oral bacterial therapy were studied in 60 elderly patients (mean age +/- SD: 76.6 +/- 5.3 years) with bowel disorders mainly represented by diarrhea accompanied by abdominal pain and meteorism. All patients were submitted to a 7-day washout followed by treatment with 6 capsules daily, each capsule containing live, lyophilized Lactobacillus acidophilus (10(9) CFU/ml). The clinical course was observed in 50 patients while the remaining 10 were hospitalized and submitted to esophago-gastro-duodenoscopy and colonoscopy both before and after treatment for withdrawal of duodenal secretion and fragments of duodenojejunal and colonic mucosa biopsies. Duodenal secretion was examined bacteriologically, and after treatment an increase of the anaerobic flora at the expense of the aerobic one was found together with improved quality of the former. Histologic examination showed reduction of the inflammatory infiltration by lymphocytes and plasma cells and increased muciparous activity of the glands. Clinically, a marked improvement of the symptoms was observed in all 60 patients.
在60例主要表现为腹泻伴腹痛和气胀的肠道疾病老年患者（平均年龄±标准差：76.6±5.3岁）中，研究了口服细菌疗法对十二指肠空肠和结肠黏膜组织学的可能有益影响及变化。所有患者均先进行7天的清洗期，随后每天服用6粒胶囊，每粒胶囊含有冻干的嗜酸乳杆菌活菌（10⁹CFU/ml）。观察了50例患者的临床病程，其余10例住院，在治疗前后接受食管胃十二指肠镜检查和结肠镜检查，以获取十二指肠分泌物以及十二指肠空肠和结肠黏膜活检组织碎片。对十二指肠分泌物进行了细菌学检查，治疗后发现厌氧菌群增加，好氧菌群减少，且前者质量有所改善。组织学检查显示淋巴细胞和浆细胞的炎性浸润减少，腺体的黏液分泌活性增加。临床上，所有60例患者的症状均有明显改善。
