De Simone C, Ciardi A, Grassi A, Lambert Gardini S, Tzantzoglou S, Trinchieri V, Moretti S, Jirillo E
Dipartimento di Medicina Sperimentale, Università dell'Aquila, Italy.
Immunopharmacol Immunotoxicol. 1992;14(1-2):331-40. doi: 10.3109/08923979209009228.
In 15 elderly individuals lyophilized Bifidobacterium bifidum (BB) and Lactobacillus acidophilus (LA) (Infloran) were administered in capsules (two capsules 4 times per day) for 28 days, while in 10 elderly controls placebo were given the same posology and for an equal period of time. The effects of this treatment on the immune system both at the periphery or the intestinal level were investigated. Results show that BB and LA significantly reduced the colonic inflammatory infiltration, without altering T, B and Leu7 + cell percentage. At the same time, a significant increase of B cell frequency in the peripheral blood was noted, in comparison to controls. The overall results suggest that the regular administration of BB and LA leads to a modulation of the immunological and inflammatory response in elderly subjects.
对15名老年人，以胶囊形式给予冻干的双歧双歧杆菌（BB）和嗜酸乳杆菌（LA）（英弗洛兰）（每天4次，每次2粒胶囊），持续28天；而对10名老年对照组给予相同剂量的安慰剂，持续相同时间。研究了这种治疗对外周或肠道水平免疫系统的影响。结果表明，BB和LA显著减少了结肠炎症浸润，而未改变T、B和Leu7 +细胞百分比。同时，与对照组相比，外周血中B细胞频率显著增加。总体结果表明，定期给予BB和LA可调节老年受试者的免疫和炎症反应。
