Vanderschueren-Lodeweyckx M, Proesmans W, Eggermont E, Eeckels R
Acta Endocrinol (Copenh). 1976 Sep;83(1):15-25. doi: 10.1530/acta.0.0830015.
The effects of the infusion in four different dosages (0.001, 0.005, 0.02 and 0.2 mg/kg/min during 60 min) of cyclic 3',5'-adenosine monophosphate and of its dibutyryl derivative on plasma growth hormone and on glucose, immunoreactive insulin and cortisol were studied in 38 normal subjects and in 10 patients with idiopathic hypopituitarism. In normal subjects cyclic 3',5'-adenosine monophosphate provokes an increase in plasma growth hormone levels (only when a dosage of 0.2 mg/kg/min is used) without any changes in plasma glucose, insulin and cortisol. The maximal value of the means is observed 75 min after starting the infusion. Dibutyryl cyclic 3',5'-adenosine monophosphate (0.2 and 0.02 mg/kg/min) provokes a dose-related rise in plasma growth hormone levels which is always preceded by hyperglycaemia and hyperinsulinaemia. The peak of the mean growth hormone levels occurs at 135 min after initiation of the infusion. In all but one hypopituitary patients the nucleotides do not promote growth hormone secretion. It is concluded that exogenous cyclic 3',5'-adenosine monophosphate and its dibutyryl derivative may not be considered as analogous and that both compounds may contribute to study growth hormone release in normal subjects and in patients with growth abnormalities.
在38名正常受试者和10名特发性垂体功能减退患者中，研究了四种不同剂量（60分钟内分别为0.001、0.005、0.02和0.2毫克/千克/分钟）的环3',5'-单磷酸腺苷及其二丁酰衍生物对血浆生长激素、葡萄糖、免疫反应性胰岛素和皮质醇的影响。在正常受试者中，环3',5'-单磷酸腺苷可使血浆生长激素水平升高（仅在使用0.2毫克/千克/分钟的剂量时），而血浆葡萄糖、胰岛素和皮质醇无任何变化。在开始输注后75分钟观察到平均值的最大值。二丁酰环3',5'-单磷酸腺苷（0.2和0.02毫克/千克/分钟）可引起血浆生长激素水平与剂量相关的升高，且总是先出现高血糖和高胰岛素血症。平均生长激素水平的峰值出现在输注开始后135分钟。除一名垂体功能减退患者外，在所有垂体功能减退患者中，核苷酸均不促进生长激素分泌。结论是，外源性环3',5'-单磷酸腺苷及其二丁酰衍生物可能不被视为类似物，且这两种化合物可能有助于研究正常受试者和生长异常患者的生长激素释放情况。
