Peracchi M, Reschini E, Cantalamessa L, Catania A, Giustina G
Metabolism. 1976 Mar;25(3):321-8. doi: 10.1016/0026-0495(76)90090-1.
The effect of somatostatin on the responses of blood glucose, plasma immunoreactive insulin (IRI), growth hormone (GH), and free fatty acids (FFA) to the injection of dibutyryl cyclic AMP (DBC) was studied in six normal volunteers. DBC, when injected alone, induced a rapid increase in blood glucose and plasma IRI levels, while GH concentrations showed a less marked and more delayed increase and plasma FFA showed a clear downtrend. Somatostatin infusion suppressed the GH and IRI release induced by DBC, potentiated its hyperglycemic effect and changed the pattern of FFA. These results suggest that somatostatin inhibits hormone secretion distal to the generation of cyclic AMP.
在六名正常志愿者中研究了生长抑素对注射二丁酰环磷腺苷（DBC）后血糖、血浆免疫反应性胰岛素（IRI）、生长激素（GH）和游离脂肪酸（FFA）反应的影响。单独注射DBC时，可使血糖和血浆IRI水平迅速升高，而GH浓度升高不明显且延迟出现，血浆FFA呈明显下降趋势。输注生长抑素可抑制DBC诱导的GH和IRI释放，增强其高血糖作用并改变FFA模式。这些结果提示生长抑素抑制环磷腺苷生成远端的激素分泌。
