创伤弧菌毒力所必需的 AphB 是一种全局调节因子的证据。
Evidence that AphB, essential for the virulence of Vibrio vulnificus, is a global regulator.
作者信息
Jeong Hee Gon, Choi Sang Ho
机构信息
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea.
出版信息
J Bacteriol. 2008 May;190(10):3768-73. doi: 10.1128/JB.00058-08. Epub 2008 Mar 14.
Abstract
The Vibrio vulnificus aphB mutant was significantly less virulent than the wild type and was impaired in motility and adherence to host cells. Microarray analysis revealed that AphB of V. vulnificus (AphB(Vv)) influences the expression of over 10% of the V. vulnificus genome. The combined results indicated that AphB(Vv) is a global regulator contributing to the pathogenesis of V. vulnificus.
摘要
创伤弧菌aphB突变体的毒力明显低于野生型，其运动性和对宿主细胞的黏附能力也受损。微阵列分析表明，创伤弧菌的AphB（AphB(Vv)）影响超过10%的创伤弧菌基因组的表达。综合结果表明，AphB(Vv)是一种参与创伤弧菌致病机制的全局调节因子。
相似文献
1
Evidence that AphB, essential for the virulence of Vibrio vulnificus, is a global regulator.创伤弧菌毒力所必需的 AphB 是一种全局调节因子的证据。
J Bacteriol. 2008 May;190(10):3768-73. doi: 10.1128/JB.00058-08. Epub 2008 Mar 14.
2
Crystal Structure of the Regulatory Domain of AphB from , a Virulence Gene Regulator.来自毒力基因调节因子 AphB 的调节结构域的晶体结构
Mol Cells. 2017 Apr;40(4):299-306. doi: 10.14348/molcells.2017.0015. Epub 2017 Apr 20.
3
Vibrio vulnificus AphB is involved in interleukin-8 production via an NF-κB-dependent pathway in human intestinal epithelial cells.创伤弧菌 AphB 通过 NF-κB 依赖途径参与人肠道上皮细胞中白细胞介素-8 的产生。
Biochem Biophys Res Commun. 2012 Jan 27;417(4):1265-70. doi: 10.1016/j.bbrc.2011.12.122. Epub 2012 Jan 3.
4
AphB influences acid tolerance of Vibrio vulnificus by activating expression of the positive regulator CadC.AphB通过激活正调控因子CadC的表达来影响创伤弧菌的耐酸性。
J Bacteriol. 2006 Sep;188(18):6490-7. doi: 10.1128/JB.00533-06.
5
LuxR homologue SmcR is essential for Vibrio vulnificus pathogenesis and biofilm detachment, and its expression is induced by host cells.LuxR 同源物 SmcR 是创伤弧菌发病机制和生物膜脱落所必需的，其表达受宿主细胞诱导。
Infect Immun. 2013 Oct;81(10):3721-30. doi: 10.1128/IAI.00561-13. Epub 2013 Jul 29.
6
IscR is a global regulator essential for pathogenesis of Vibrio vulnificus and induced by host cells.IscR是创伤弧菌致病所必需的一种全局调控因子，由宿主细胞诱导产生。
Infect Immun. 2014 Feb;82(2):569-78. doi: 10.1128/IAI.01141-13. Epub 2013 Nov 18.
7
RtxA1 Toxin Expression Upon Contact With Host Cells Is RpoS-Dependent.与宿主细胞接触时，RtxA1 毒素的表达依赖于 RpoS。
Front Cell Infect Microbiol. 2018 Mar 15;8:70. doi: 10.3389/fcimb.2018.00070. eCollection 2018.
8
Identification and functional analysis of vibrio vulnificus SmcR, a novel global regulator.创伤弧菌新型全局调控因子SmcR的鉴定与功能分析
J Microbiol Biotechnol. 2007 Feb;17(2):325-34.
9
Regulation of fatty acid metabolism by FadR is essential for Vibrio vulnificus to cause infection of mice.FadR对脂肪酸代谢的调控对于创伤弧菌引起小鼠感染至关重要。
J Bacteriol. 2008 Dec;190(23):7633-44. doi: 10.1128/JB.01016-08. Epub 2008 Oct 3.
10
The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections.调控子 HlyU、RTX 毒素基因 rtxA1 及其在创伤弧菌感染发病机制中的作用。
Microbiologyopen. 2012 Dec;1(4):502-13. doi: 10.1002/mbo3.48. Epub 2012 Nov 28.
引用本文的文献
1
The Interplay of AphB and CadC to Activate Acid Resistance of .AphB 和 CadC 相互作用激活. 的酸抗性
J Bacteriol. 2023 Apr 25;205(4):e0045722. doi: 10.1128/jb.00457-22. Epub 2023 Mar 15.
2
Structural Insights into Regulation of Vibrio Virulence Gene Networks.结构洞察弧菌毒力基因网络的调控。
Adv Exp Med Biol. 2023;1404:269-294. doi: 10.1007/978-3-031-22997-8_14.
3
Targeting Virulence Genes Expression in by Alternative Carbon Sources.通过替代碳源靶向调控 的毒力基因表达。
Int J Mol Sci. 2022 Dec 3;23(23):15278. doi: 10.3390/ijms232315278.
4
Motility of Vibrio spp.: regulation and controlling strategies.弧菌属的运动性：调控与控制策略
Appl Microbiol Biotechnol. 2020 Oct;104(19):8187-8208. doi: 10.1007/s00253-020-10794-7. Epub 2020 Aug 20.
5
A MARTX Toxin Gene Is Controlled by Host Environmental Signals through a CRP-Coordinated Regulatory Network in Vibrio vulnificus.一种 MARTX 毒素基因通过副溶血性弧菌中的 CRP 协调调控网络受宿主环境信号控制。
mBio. 2020 Jul 28;11(4):e00723-20. doi: 10.1128/mBio.00723-20.
6
The role of Vibrio vulnificus virulence factors and regulators in its infection-induced sepsis.创伤弧菌毒力因子及其调控因子在其感染诱导的败血性休克中的作用。
Folia Microbiol (Praha). 2020 Apr;65(2):265-274. doi: 10.1007/s12223-019-00763-7. Epub 2019 Dec 16.
7
Identification and characterization of encoding a phospholipase A essential for pathogenesis.鉴定和表征一种对发病机制至关重要的磷脂酶A的编码。
J Biol Chem. 2017 Oct 13;292(41):17129-17143. doi: 10.1074/jbc.M117.791657. Epub 2017 Aug 30.
8
Lrp, a global regulator, regulates the virulence of Vibrio vulnificus.Lrp 是一种全局性调控因子，可调节创伤弧菌的毒力。
J Biomed Sci. 2017 Aug 11;24(1):54. doi: 10.1186/s12929-017-0361-9.
9
Identification of the Regulon of AphB and Its Essential Roles in LuxR and Exotoxin Asp Expression in the Pathogen Vibrio alginolyticus.溶藻弧菌中 AphB 调控子的鉴定及其在 LuxR 和外毒素 Asp 表达中的重要作用
J Bacteriol. 2017 Sep 19;199(20). doi: 10.1128/JB.00252-17. Print 2017 Oct 15.
10
Crystal Structure of the Regulatory Domain of AphB from , a Virulence Gene Regulator.来自毒力基因调节因子 AphB 的调节结构域的晶体结构
Mol Cells. 2017 Apr;40(4):299-306. doi: 10.14348/molcells.2017.0015. Epub 2017 Apr 20.
本文引用的文献
1
The Mga virulence regulon: infection where the grass is greener.Mga 毒力调节子：草更绿的地方的感染
Mol Microbiol. 2007 Dec;66(5):1056-65. doi: 10.1111/j.1365-2958.2007.06006.x.
2
Implication of quorum sensing in Salmonella enterica serovar typhimurium virulence: the luxS gene is necessary for expression of genes in pathogenicity island 1.群体感应在鼠伤寒沙门氏菌毒力中的作用：luxS基因对于毒力岛1中基因的表达是必需的。
Infect Immun. 2007 Oct;75(10):4885-90. doi: 10.1128/IAI.01942-06. Epub 2007 Jul 9.
3
4
FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar Typhimurium (ATCC 14028s).FNR是鼠伤寒沙门氏菌（ATCC 14028s）中毒力和厌氧代谢的全局调节因子。
J Bacteriol. 2007 Mar;189(6):2262-73. doi: 10.1128/JB.00726-06. Epub 2007 Jan 12.
5
Identification of OmpU of Vibrio vulnificus as a fibronectin-binding protein and its role in bacterial pathogenesis.创伤弧菌外膜蛋白U作为纤连蛋白结合蛋白的鉴定及其在细菌致病机制中的作用。
Infect Immun. 2006 Oct;74(10):5586-94. doi: 10.1128/IAI.00171-06.
6
AphB influences acid tolerance of Vibrio vulnificus by activating expression of the positive regulator CadC.AphB通过激活正调控因子CadC的表达来影响创伤弧菌的耐酸性。
J Bacteriol. 2006 Sep;188(18):6490-7. doi: 10.1128/JB.00533-06.
7
Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence.创伤弧菌wbpP基因的鉴定及其毒力作用评估。
Infect Immun. 2006 Jan;74(1):721-8. doi: 10.1128/IAI.74.1.721-728.2006.
8
CadC activates pH-dependent expression of the Vibrio vulnificus cadBA operon at a distance through direct binding to an upstream region.CadC通过直接结合到上游区域，远距离激活创伤弧菌cadBA操纵子的pH依赖性表达。
J Bacteriol. 2005 Nov;187(22):7870-5. doi: 10.1128/JB.187.22.7870-7875.2005.
9
A Vibrio vulnificus type IV pilin contributes to biofilm formation, adherence to epithelial cells, and virulence.创伤弧菌IV型菌毛蛋白有助于生物膜形成、对上皮细胞的黏附及毒力。
Infect Immun. 2005 Mar;73(3):1411-22. doi: 10.1128/IAI.73.3.1411-1422.2005.
10
Cyclic di-GMP as a bacterial second messenger.环二鸟苷单磷酸作为一种细菌第二信使。
Microbiology (Reading). 2004 Aug;150(Pt 8):2497-2502. doi: 10.1099/mic.0.27099-0.
Zotero 插件