Miyagawa M, Tanada S, Hamamoto K
Department of Radiology, School of Medicine, Ehime University, Japan.
Eur J Nucl Med. 1991;18(5):332-8. doi: 10.1007/BF02285461.
To evaluate the usefulness of myocardial scintigraphy as a monitoring tool for chronic doxorubicin (DXR) cardiotoxicity, a rat model was used to investigate the relationship between the myocardial uptake of thallium 201 (Tl) or rechnetium 99m pyrophosphate (99mTc-PPi) and histological changes of the heart. Although there was no significant difference in myocardial Tl uptake between control and DXR-treated rats at an early phase after Tl injection, late-phase Tl uptake was significantly higher in the DXR-treated rats than in the control rats, indicating a slow wash-out of Tl from the myocardium. The wash-out rate calculated from scintigraphic examination of DXR-treated rats was significantly decreased with increasing degree of cardiomyopathy. Since the Tl wash-out rate was sharply decreased even in animals with minimal histological changes, it may be a possible monitoring tool for the early detection of chronic DXR cardiotoxicity. On the other hand, myocardial 99mTc-PPi images could be obtained only in rats with severe myocardial changes and hence would not useful for early detection.
为评估心肌闪烁显像作为慢性阿霉素（DXR）心脏毒性监测工具的实用性，采用大鼠模型研究了铊201（Tl）或锝99m焦磷酸盐（99mTc-PPi）心肌摄取与心脏组织学变化之间的关系。虽然在注射Tl后的早期阶段，对照组和DXR处理组大鼠的心肌Tl摄取没有显著差异，但在晚期，DXR处理组大鼠的Tl摄取显著高于对照组大鼠，这表明Tl从心肌的清除缓慢。根据对DXR处理组大鼠的闪烁显像检查计算出的清除率，随着心肌病程度的增加而显著降低。由于即使在组织学变化最小的动物中，Tl清除率也急剧下降，因此它可能是早期检测慢性DXR心脏毒性的一种可能的监测工具。另一方面，心肌99mTc-PPi图像仅能在有严重心肌变化的大鼠中获得，因此对早期检测没有用处。
