Vejtorp M, Vejerslev L O, Ruge S
Department of Gynaecology and Obstetrics, Hvidovre Hospital, Denmark.
Hum Reprod. 1989 May;4(4):464-7. doi: 10.1093/oxfordjournals.humrep.a136927.
Eleven women with small unruptured tubal pregnancies were treated by laparoscopically guided injection of prostaglandin F2 alpha in the oviduct and in the ovary which contained the corpus luteum. They had no side effects of the treatment and were discharged from hospital 1-3 days later. In 10 women the serum concentration of human chorionic gonadotrophin (HCG) decreased to less than 20 IU/l in a median time of 7.5 days, the range being 1-46 days. One woman required an operation 6 days after the treatment as her serum HCG level was stationary and she continued to have abdominal pain. Hysterosalpingography 3 months after the treatment showed patency of the oviduct on the side of the pregnancy in seven of the eight women who have been examined. We conclude that the injection of prostaglandin F2 alpha seems to promote the resolution of selected tubal pregnancies.
11名输卵管妊娠未破裂的女性接受了腹腔镜引导下向输卵管及含有黄体的卵巢内注射前列腺素F2α的治疗。她们没有出现治疗的副作用，并于1 - 3天后出院。10名女性的血清人绒毛膜促性腺激素（HCG）浓度在中位时间7.5天（范围为1 - 46天）降至低于20 IU/l。1名女性在治疗6天后需要进行手术，因为她的血清HCG水平稳定且持续腹痛。治疗3个月后的子宫输卵管造影显示，接受检查的8名女性中有7名妊娠侧输卵管通畅。我们得出结论，注射前列腺素F2α似乎有助于某些输卵管妊娠的消退。
