Jensen Patricia, Farago Anna F, Awatramani Rajeshwar B, Scott Michael M, Deneris Evan S, Dymecki Susan M
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Nat Neurosci. 2008 Apr;11(4):417-9. doi: 10.1038/nn2050. Epub 2008 Mar 16.
Central serotonin-producing neurons are heterogeneous-differing in location, morphology, neurotoxin sensitivity and associated clinical disorders-but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.
中枢5-羟色胺生成神经元具有异质性——在位置、形态、神经毒素敏感性及相关临床疾病方面存在差异——但这种异质性的基础很大程度上尚不清楚，区分5-羟色胺能神经元生理亚型的标志物也是如此。在此，我们基于在祖细胞中差异激活的基因程序重新定义了5-羟色胺能亚型。我们揭示了一个以基因谱系为基础的5-羟色胺能系统分子框架，该框架可能具有生理相关性，并将允许获取经基因定义的亚型以进行操控。
