一种用于基于质谱的蛋白质组学的定量分析软件工具。
A quantitative analysis software tool for mass spectrometry-based proteomics.
作者信息
Park Sung Kyu, Venable John D, Xu Tao, Yates John R
机构信息
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR11, La Jolla, California 92014, USA.
出版信息
Nat Methods. 2008 Apr;5(4):319-22. doi: 10.1038/nmeth.1195. Epub 2008 Mar 16.
Abstract
We describe Census, a quantitative software tool compatible with many labeling strategies as well as with label-free analyses, single-stage mass spectrometry (MS1) and tandem mass spectrometry (MS/MS) scans, and high- and low-resolution mass spectrometry data. Census uses robust algorithms to address poor-quality measurements and improve quantitative efficiency, and it can support several input file formats. We tested Census with stable-isotope labeling analyses as well as label-free analyses.
摘要
我们介绍了Census，这是一种定量软件工具，它与多种标记策略以及无标记分析、单级质谱（MS1）和串联质谱（MS/MS）扫描以及高分辨率和低分辨率质谱数据兼容。Census使用强大的算法来处理质量较差的测量结果并提高定量效率，并且它可以支持多种输入文件格式。我们用稳定同位素标记分析以及无标记分析对Census进行了测试。
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