大肠杆菌葡糖醛酸基合成酶：一种用于合成β-葡糖醛酸苷的工程酶。
Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of beta-glucuronides.
作者信息
Wilkinson Shane M, Liew Chu W, Mackay Joel P, Salleh Hamzah M, Withers Stephen G, McLeod Malcolm D
机构信息
School of Chemistry, University of Sydney, NSW 2006, Australia.
出版信息
Org Lett. 2008 Apr 17;10(8):1585-8. doi: 10.1021/ol8002767. Epub 2008 Mar 18.
PMID:18345681
Abstract
The glycosynthase derived from E. coli beta-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of beta-glucuronides under mild conditions.
摘要
源自大肠杆菌β-葡萄糖醛酸酶的糖基合酶能催化一系列伯醇、仲醇和芳基醇的葡萄糖醛酸化反应，产率适中至优异。该方法在温和条件下提供了一种高效、立体选择性且可扩展的一步法合成β-葡萄糖醛酸苷的方法。
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