Cornia Paul B, Davidson Heather L, Lipsky Benjamin A
University of Washington School of Medicine, Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System and Department of Medicine, Seattle, WA 98108-1597, USA.
Expert Opin Pharmacother. 2008 Apr;9(5):717-30. doi: 10.1517/14656566.9.5.717.
Skin and skin structure infections are frequently encountered in clinical practice. Fortunately, these infections usually produce only mild to moderate symptoms and signs. Some, however, are severe and may even be life-threatening.
To review the approach to the evaluation and treatment of patients with complicated skin and skin structure infections and to discuss when to consider using either established antibiotics or recently licensed agents for treating these infections.
In addition to a non-systematic literature review of complicated skin and skin structure infections and necrotizing fasciitis, we identified recent articles examining the microbiology and describing recently licensed antibiotics for treating these infections.
RESULTS/CONCLUSIONS: Clinicians must learn to recognize the early symptoms and signs of severe skin and skin structure infections to ensure they select appropriate empiric antibiotic therapy and, when needed, obtain prompt surgical consultation. While the recent approvals of new agents for treating these infections are welcome, particularly in light of the continued emergence of antibiotic-resistant bacteria, traditional antibiotic regimens remain appropriate for most cases.
皮肤及皮肤结构感染在临床实践中经常遇到。幸运的是，这些感染通常仅产生轻至中度的症状和体征。然而，有些感染很严重，甚至可能危及生命。
回顾复杂皮肤及皮肤结构感染患者的评估和治疗方法，并讨论何时考虑使用已有的抗生素或最近获批的药物来治疗这些感染。
除了对复杂皮肤及皮肤结构感染和坏死性筋膜炎进行非系统性文献综述外，我们还检索了近期研究这些感染微生物学以及描述用于治疗这些感染的最近获批抗生素的文章。
结果/结论：临床医生必须学会识别严重皮肤及皮肤结构感染的早期症状和体征，以确保选择合适的经验性抗生素治疗，并在需要时及时获得外科会诊。虽然最近有新的药物获批用于治疗这些感染，特别是考虑到抗生素耐药菌的持续出现，但传统的抗生素治疗方案在大多数情况下仍然适用。
