Gamborg Nielsen P
Department of Dermatology, Varberg Hospital, Sweden.
Int J Dermatol. 1991 Sep;30(9):662-6. doi: 10.1111/j.1365-4362.1991.tb03499.x.
Two percent metronidazole and 5% benzoyl peroxide cream was evaluated in four clinical trials. It could be shown that this test cream was significantly better than 5% benzoyl peroxide jelly alone, and significantly better than a placebo cream. It was also shown that 2% metronidazole and 5% benzoyl peroxide cream was equal to systemic oxytetracycline therapy. The advisability of the combination of metronidazole and benzoyl peroxide was simultaneously discussed.
