Garcia-Plata D, Mozos E, Sierra M A, Peña J, Solana R
Department of Biochemistry, University of Córdoba, Spain.
Invasion Metastasis. 1991;11(3):166-73.
Decreased expression of MHC class I molecules in tumor cells has been reported to be associated with enhanced malignancy both in human and murine tumors. This paper studies HLA-ABC and HLA-DR expression in 56 basal cell carcinomas. Our results show that these tumors have a heterogeneous expression of MHC class I molecules: 11% exhibit uniform staining of most tumor cells; 25% are only partially positive, and the remaining 64% are MHC class I negative. A positive correlation between the level of HLA-ABC molecule expression and the degree of histological differentiation has been found. The expression pattern of tumor cells with anti-class II monoclonal antibodies shows weak homogeneous staining in 5%, staining in only a few areas of the tumor in 32%, whereas 63% has no significant staining for MHC class II antigens. Most mononuclear cells infiltrating the tumor were T lymphocytes (CD-3 positive). Results also show that 68% of the tumors express class II molecules homogeneously in the infiltrate. The expression of class II antigens in infiltrating lymphocytes correlated with the level of class II expression in the tumor cells probably as a consequence of lymphokine production by activated T cells.
据报道，肿瘤细胞中MHC I类分子表达降低与人类和鼠类肿瘤的恶性程度增加有关。本文研究了56例基底细胞癌中HLA - ABC和HLA - DR的表达情况。我们的结果显示，这些肿瘤中MHC I类分子表达具有异质性：11%的肿瘤大多数细胞呈现均匀染色；25%仅部分呈阳性，其余64%为MHC I类阴性。已发现HLA - ABC分子表达水平与组织学分化程度呈正相关。用抗II类单克隆抗体检测肿瘤细胞的表达模式显示，5%呈现弱的均匀染色，32%仅在肿瘤的少数区域有染色，而63%对MHC II类抗原无明显染色。浸润肿瘤的大多数单核细胞为T淋巴细胞（CD - 3阳性）。结果还显示，68%的肿瘤在浸润细胞中均匀表达II类分子。浸润淋巴细胞中II类抗原的表达与肿瘤细胞中II类分子的表达水平相关，这可能是活化T细胞产生淋巴因子的结果。
