García-Plata D, Mozos E, Carrasco L, Solana R
Department of Dermatology, University of Córdoba, Spain.
Histol Histopathol. 1993 Apr;8(2):219-26.
A correlation between the lack of MHC class I gene expression on murine tumor cells and their ability to grow and metastasize has recently been established. This paper studies HLA-ABC and HLA-DR antigen expression in tumor cells and mononuclear infiltrate of 26 cutaneous squamous cell carcinomas (SCC). Our results showed a heterogeneous expression of HLA class I molecules in these tumors. No significant correlation between the degree of HLA class I molecule expression and anatomical-clinical parameters was found. Class II antigen expression was correlated to the histopathological type and to the degree of cell differentiation. Most mononuclear cells infiltrating the tumor were T-lymphocytes. No correlation with anatomical-clinical parameters was found.
最近已证实小鼠肿瘤细胞上缺乏MHC I类基因表达与其生长和转移能力之间存在相关性。本文研究了26例皮肤鳞状细胞癌（SCC）肿瘤细胞和单核浸润细胞中HLA-ABC和HLA-DR抗原的表达情况。我们的结果显示这些肿瘤中HLA I类分子表达具有异质性。未发现HLA I类分子表达程度与解剖学-临床参数之间存在显著相关性。II类抗原表达与组织病理学类型及细胞分化程度相关。浸润肿瘤的大多数单核细胞是T淋巴细胞。未发现其与解剖学-临床参数相关。
