Devos Steven A, Constandt Lieve, Tupker Ron A, Noz Kathy C, Lucker Georges P H, Bruynzeel Derk P, Schuttelaar Marie-Louise A, Kruyswijk Mente R J, van Zuuren Esther J, Vink Jaqueline, Coenraads Pieter-Jan, Kiemeney Lambertus A L M, van der Valk Pieter G M
Department of Dermatology, Hospital H. Serruys, Ostend, Belgium.
Dermatitis. 2008 Jan-Feb;19(1):43-7.
Fragrances are an important cause of allergic contact dermatitis. We presume that the traditional fragrance mix (FM) detects 70 to 80% of fragrance-allergic patients. FM has an irritant potential. Weak positive reactions may have a greater chance of being irrelevant than strong reactions.
To improve the appraisal of FM patch-test reactions, we studied the relevance of reactions of different strength. We also studied the predictive value of the following on the relevance of the initial FM patch-test results: patch-test results of a repeated FM test; results of patch tests with balsam of Peru, colophony, and ingredients of the mix; and (history of) atopic dermatitis.
One hundred thirty-eight patients who had doubtful positive (?+) or positive (+ to +++) reactions were included in the study. We determined relevance by history taking, location and course of the dermatitis, and additional patch testing. Patients were retested with FM and with each ingredient separately.
The relevance of reactions to FM increases with the strength of the reactions. Predictors of relevance are the results of retesting with FM, the results of tests with the ingredients, and a history and/or present symptoms of atopic dermatitis.
Retesting with FM and its ingredients may add to the benefit of patch testing.
香料是过敏性接触性皮炎的重要病因。我们推测传统香料混合物（FM）能检测出70%至80%的香料过敏患者。FM有潜在刺激性。弱阳性反应比强阳性反应更有可能不具有相关性。
为了改进对FM斑贴试验反应的评估，我们研究了不同强度反应的相关性。我们还研究了以下因素对初始FM斑贴试验结果相关性的预测价值：重复FM试验的斑贴试验结果；秘鲁香脂、松香及混合物成分的斑贴试验结果；以及特应性皮炎（病史）。
138例有可疑阳性（?+）或阳性（+至+++）反应的患者纳入研究。我们通过病史采集、皮炎的部位和病程以及额外的斑贴试验来确定相关性。患者分别用FM及每种成分重新进行检测。
对FM反应的相关性随反应强度增加。相关性的预测因素是FM重新检测的结果、成分检测的结果以及特应性皮炎的病史和/或当前症状。
用FM及其成分重新检测可能会增加斑贴试验的益处。
