Larsen W, Nakayama H, Fischer T, Elsner P, Frosch P, Burrows D, Jordan W, Shaw S, Wilkinson J, Marks J, Sugawara M, Nethercott M, Nethercottdagger J
2250 NW Flanders, Suite 205, Portland, Oregon 97210-3488, USA.
Am J Contact Dermat. 1998 Dec;9(4):202-6.
To determine the frequency of responses to four mixtures of fragrance materials in routine clinic patients undergoing patch testing for suspect allergic contact dermatitis. The validity of using fragrance mixtures alone, or in combination, was evaluated in terms of predicting allergy to fragrance judged on the basis of finding a response to at least one of the fragrance mixtures.
A total of 752 subjects were patch tested in five centers worldwide with (1) fragrance mix 8% (FM), (2) balsam of Peru 25%, (3) a mixture of seven of the eight FM 8% ingredients and other fragrance ingredients including jasmine absolute (jasmine/FM mix), and (4) a mixture of five selected natural fragrance ingredients (NM).
Of 752 subjects, 100 (13%) had positive patch tests to at least one of the four fragrance mixtures. The age of the patients was 45.2 +/- 18.3 years (mean +/- SD). Ninety-six percent were Caucasian. Facial eruptions and hand involvement were the most common topographic sites. Of subjects exhibiting a positive response, 67% reacted to FM, 63% to the jasmine/FM mix, 47% to the NM, and 38% to balsam of Peru. Testing with FM and NM identified 84% of the perfume-allergic patients. FM 8% tested simultaneously with the jasmine/FM mix identified 86% of the perfume-allergic patients. Testing simultaneously with three test materials combining either the NM or the jasmine/FM mix with balsam of Peru and FM identified 95% of the perfume-sensitive patients.
The simultaneous testing of NM or jasmine/FM mix, in addition to the conventional use of FM 8% and balsam of Peru, increases the sensitivity of testing for fragrance allergy from 81% to 95%.
确定在因疑似过敏性接触性皮炎而接受斑贴试验的门诊患者中，对四种香料混合物产生反应的频率。根据对至少一种香料混合物产生反应来判断香料过敏情况，评估单独使用或联合使用香料混合物进行预测的有效性。
全球五个中心共752名受试者接受了斑贴试验，使用的材料包括：（1）8%香料混合物（FM）；（2）25%秘鲁香脂；（3）8%FM的八种成分中的七种与包括茉莉净油在内的其他香料成分的混合物（茉莉/FM混合物）；（4）五种选定天然香料成分的混合物（NM）。
752名受试者中，100名（13%）对四种香料混合物中的至少一种斑贴试验呈阳性。患者年龄为45.2±18.3岁（均值±标准差）。96%为白种人。面部皮疹和手部受累是最常见的发病部位。在呈阳性反应的受试者中，67%对FM有反应，63%对茉莉/FM混合物有反应，47%对NM有反应，38%对秘鲁香脂有反应。使用FM和NM检测出84%的香水过敏患者。8%FM与茉莉/FM混合物同时检测出86%的香水过敏患者。同时使用三种检测材料，将NM或茉莉/FM混合物与秘鲁香脂和FM联合检测，识别出95%的香水敏感患者。
除了常规使用8%FM和秘鲁香脂外，同时检测NM或茉莉/FM混合物可将香料过敏检测的敏感性从81%提高到95%。
