促炎信号在新生儿坏死性小肠结肠炎中的重要性。
The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis.
作者信息
Frost Brandy L, Jilling Tamas, Caplan Michael S
机构信息
Department of Pediatrics, Evanston Northwestern Healthcare/Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA.
出版信息
Semin Perinatol. 2008 Apr;32(2):100-6. doi: 10.1053/j.semperi.2008.01.001.
Abstract
Despite modern medical advances, necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in neonatal intensive care units, affecting 10% of premature neonates born weighing less than 1500 g. Although many advances have been made in the understanding of NEC, the etiology and pathophysiology remain incompletely understood, and treatment is limited to supportive care. In recent years, many studies have evaluated the inflammatory cascade that is central to the disease process, and research is ongoing into strategies to prevent and/or ameliorate neonatal NEC. In this review, we examine the key points in the signaling pathways involved in NEC, and potential strategies for prevention and treatment of this dreaded disease.
摘要
尽管现代医学取得了进步，但坏死性小肠结肠炎（NEC）仍是新生儿重症监护病房发病和死亡的重要原因，影响10%体重小于1500克的早产儿。虽然在对NEC的认识方面已经取得了许多进展，但其病因和病理生理学仍未完全了解，治疗仅限于支持性护理。近年来，许多研究评估了在疾病过程中起核心作用的炎症级联反应，并且针对预防和/或改善新生儿NEC的策略的研究正在进行中。在本综述中，我们研究了NEC相关信号通路中的关键点，以及预防和治疗这种可怕疾病的潜在策略。
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