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1
Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C.胰岛素通过GRK2介导的受体磷酸化作用，涉及磷脂酰肌醇3激酶和蛋白激酶C，导致肾多巴胺D1受体脱敏。
Am J Physiol Renal Physiol. 2007 Sep;293(3):F877-84. doi: 10.1152/ajprenal.00184.2007. Epub 2007 Jun 13.
2
Oxidative stress reduces renal dopamine D1 receptor-Gq/11alpha G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2.氧化应激通过G蛋白偶联受体激酶2降低肾脏多巴胺D1受体-Gq/11α G蛋白-磷脂酶C信号传导。
Am J Physiol Renal Physiol. 2007 Jul;293(1):F306-15. doi: 10.1152/ajprenal.00108.2007. Epub 2007 Apr 25.
3
The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production.人GRK4γ A142V转基因小鼠的血压升高与活性氧生成增加无关。
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2083-92. doi: 10.1152/ajpheart.00944.2006. Epub 2007 Jan 26.
4
Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6).多巴胺D1样受体介导的对大鼠肠上皮IEC-6细胞中Cl/HCO3-交换体活性的抑制作用受G蛋白偶联受体激酶6（GRK 6）调控。
Cell Physiol Biochem. 2006;18(6):347-60. doi: 10.1159/000097612.
5
Population-based sample reveals gene-gender interactions in blood pressure in White Americans.基于人群的样本揭示了美国白人血压中的基因-性别相互作用。
Hypertension. 2007 Jan;49(1):96-106. doi: 10.1161/01.HYP.0000252029.35106.67. Epub 2006 Dec 11.
6
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.血管紧张素II通过其在肾脏中的受体导致高血压和心脏肥大。
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90. doi: 10.1073/pnas.0605545103. Epub 2006 Nov 7.
7
Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity.疾病机制：GRK4在原发性高血压病因及盐敏感性中的作用
Nat Clin Pract Nephrol. 2006 Nov;2(11):637-50. doi: 10.1038/ncpneph0301.
8
Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.中国北方汉族人群中G蛋白偶联受体激酶4基因变异与原发性高血压的关联研究
Ann Hum Genet. 2006 Nov;70(Pt 6):778-83. doi: 10.1111/j.1469-1809.2006.00278.x.
9
D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension.高血压患者肾近端小管中D1多巴胺受体的过度磷酸化
Kidney Int. 2006 Sep;70(6):1072-9. doi: 10.1038/sj.ki.5001708. Epub 2006 Jul 19.
10
Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats.氧化应激在老年Fischer 344大鼠肾多巴胺D1受体-G蛋白偶联及功能缺陷中的作用
Am J Physiol Renal Physiol. 2006 Nov;291(5):F945-51. doi: 10.1152/ajprenal.00111.2006. Epub 2006 Jun 6.

G protein-coupled receptor kinase 4: role in blood pressure regulation.

作者信息

Zeng Chunyu, Villar Van Anthony M, Eisner Gilbert M, Williams Scott M, Felder Robin A, Jose Pedro A

机构信息

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing City, People's Republic of China.

出版信息

Hypertension. 2008 Jun;51(6):1449-55. doi: 10.1161/HYPERTENSIONAHA.107.096487. Epub 2008 Mar 17.

DOI:10.1161/HYPERTENSIONAHA.107.096487
PMID:18347232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3722601/
Abstract
摘要