Forsling M L, Kelestimur H, Windle R
Department of Gynaecology, UMDS, St Thomas' Campus, London.
J Endocrinol. 1991 Sep;130(3):387-93. doi: 10.1677/joe.0.1300387.
It has been shown that surgical ovariectomy of the rat results in a fall in plasma vasopressin concentrations suggesting that ovarian steroids may influence hormone release. To determine whether a similar fall is found on suppression of the oestrous cycle, vasopressin concentrations were monitored after treatment with the antioestrogen preparation tamoxifen or a long-acting analogue of LH-releasing hormone (LHRH) which suppresses ovarian function. Treatment with either agent was found to result in a fall in circulating vasopressin concentrations, with little effect on fluid balance. To determine whether the ovary could influence the vasopressin release in response to known stimuli, hormone concentrations were measured in ovariectomized animals during extracellular fluid hypertonicity produced by an i.p. injection of hypertonic saline and hypovolaemia produced by an i.p. injection of polyethylene glycol. It was found that after ovariectomy or treatment with tamoxifen, the response to hypertonicity was unaffected but that to hypovolaemia was attenuated. Treatment with LHRH affected the response to both hypovolaemia and hypertonicity.
已表明，对大鼠进行手术切除卵巢会导致血浆血管加压素浓度下降，这表明卵巢类固醇可能会影响激素释放。为了确定在抑制发情周期时是否会出现类似的下降，在用抗雌激素制剂他莫昔芬或抑制卵巢功能的促黄体生成素释放激素（LHRH）长效类似物治疗后，监测血管加压素浓度。发现用这两种药物治疗都会导致循环血管加压素浓度下降，对水平衡影响很小。为了确定卵巢是否能影响对已知刺激的血管加压素释放，在腹腔注射高渗盐水产生细胞外液高渗和腹腔注射聚乙二醇产生低血容量期间，测量去卵巢动物的激素浓度。发现去卵巢或用他莫昔芬治疗后，对高渗的反应未受影响，但对低血容量的反应减弱。用LHRH治疗会影响对低血容量和高渗的反应。
