Forsling M L, Peysner K
Department of Physiology, University College, London.
J Endocrinol. 1988 Jun;117(3):397-402. doi: 10.1677/joe.0.1170397.
Observations were made of fluid balance and vasopressin concentrations throughout the oestrous cycle of normally cyclic female rats housed under a 12 h light: 12 h darkness regime. Plasma vasopressin concentrations were found to increase progressively during the light period, falling again during the night on all days of the cycle except pro-oestrus. On this day, peak vasopressin concentrations of 3.32 +/- 0.8 pmol/l were seen between 10.00 and 12.00 h, with lower concentrations of 1.74 +/- 0.22 pmol/l being seen between 18.00 and 19.00 h. Urine flow appeared to reflect the changes in plasma vasopressin concentrations, being significantly lower during the light phase, with a small increase being seen over this period on pro-oestrus. Pituitary vasopressin concentrations were highest between 09.00 and 10.00 h and fell progressively over each of the 4 days of the oestrous cycle. The changes in pituitary content were greater than could be accounted for in terms of the alterations in the plasma concentrations of vasopressin.
对处于12小时光照：12小时黑暗周期条件下的正常发情周期雌性大鼠发情周期全过程的液体平衡和抗利尿激素浓度进行了观察。发现血浆抗利尿激素浓度在光照期逐渐升高，在除发情前期外的周期各天夜间又下降。在发情前期这天，10:00至12:00观察到抗利尿激素浓度峰值为3.32±0.8 pmol/l，18:00至19:00观察到较低浓度为1.74±0.22 pmol/l。尿流量似乎反映了血浆抗利尿激素浓度的变化，在光照期显著降低，在发情前期该时段有小幅增加。垂体抗利尿激素浓度在09:00至10:00最高，在发情周期的4天中逐渐下降。垂体含量的变化大于根据血浆抗利尿激素浓度变化所能解释的范围。
