他莫昔芬治疗涎腺腺样囊性癌：2例报告
Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases.
作者信息
Elkin Adam D, Jacobs Charlotte D
机构信息
Department of Medicine, Stanford University School of Medicine, Stanford Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305, USA.
出版信息
J Cancer Res Clin Oncol. 2008 Oct;134(10):1151-3. doi: 10.1007/s00432-008-0377-3. Epub 2008 Mar 18.
Abstract
PURPOSE
Adenoid cystic carcinoma of the salivary gland (ACC-SG) is a slow-growing tumor that is refractory to most chemotherapeutic agents. Estrogen receptor (ER) antagonists provide a novel approach for recurrent disease.
METHODS
We report two cases of ACC-SC in which Tamoxifen/Toremifene were used.
RESULTS
Both patients obtained long-term stability of disease with no associated toxicity.
CONCLUSIONS
Given the relatively unsuccessful treatments for ACC-SC and the low toxicity of ER antagonists, such therapy should be considered in these patients for its potential disease-stabilizing effects.
摘要
目的
涎腺腺样囊性癌（ACC-SG）是一种生长缓慢的肿瘤，对大多数化疗药物均耐药。雌激素受体（ER）拮抗剂为复发性疾病提供了一种新的治疗方法。
方法
我们报告了2例使用他莫昔芬/托瑞米芬治疗的ACC-SC病例。
结果
两名患者均获得了疾病的长期稳定，且无相关毒性。
结论
鉴于ACC-SC的治疗相对不太成功，且ER拮抗剂毒性较低，应考虑对这些患者采用此类治疗，因其具有潜在的疾病稳定作用。
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