Dori S, Trougouboff P, David R, Buchner A
Department of Oral and Maxillofacial Surgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Oral Oncol. 2000 Sep;36(5):450-3. doi: 10.1016/s1368-8375(00)00029-4.
Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary gland origin, which is characterized by a high rate of local recurrence and distant metastasis even after aggressive surgical treatment. In several studies using various immunohistochemical techniques, estrogen and progesterone receptor (ER and PgR) proteins in salivary gland ACC have been identified and the possible use of endocrine therapy as a treatment modality suggested. On this basis, 27 samples of formalin-fixed paraffin-embedded salivary gland ACC were immunohistochemically evaluated for the presence of ER and PgR. ER was not detected in any of the tumors and PgR was identified in only two cases. Thus, application of hormone therapy to salivary gland ACC is not supported by the results of the present study.
腺样囊性癌（ACC）是一种起源于唾液腺的恶性肿瘤，其特点是即使经过积极的手术治疗，局部复发和远处转移率仍很高。在几项使用各种免疫组织化学技术的研究中，已在唾液腺ACC中鉴定出雌激素和孕激素受体（ER和PgR）蛋白，并提出了将内分泌治疗作为一种治疗方式的可能性。在此基础上，对27例福尔马林固定石蜡包埋的唾液腺ACC样本进行免疫组织化学评估，以检测ER和PgR的存在。在任何肿瘤中均未检测到ER，仅在两例中鉴定出PgR。因此，本研究结果不支持对唾液腺ACC应用激素治疗。
