Lampert F, Harbott J, Ritterbach J
Abteilung für Allgemeine Pädiatrie, Hämatologie und Onkologie, Universitäts-Kinderklinik Giessen.
Klin Padiatr. 1991 Jul-Aug;203(4):311-8. doi: 10.1055/s-2007-1025446.
Leukemia karyotypes were analyzed in 792 children with acute lymphoblastic leukemia (ALL) and 217 patients with acute myelocytic leukemia (AML). These patients were registered and uniformly treated in German multicentre trials from 1984-01-01 to 1989-12-31. In distinct leukemia subgroups specific chromosome abnormalities were found: Numerical aberrations such as hyperdiploidy over 50 chromosomes in c-ALL or structural aberrations (translocations) such as t(8;14) in B-ALL, t(11;14) in T-ALL, t(4;11) in ppB-ALL, t(1;19) in pB-ALL, t(15;17) in AML-M3, t(8;21) in AML-M2. Prognostic significance of the leukemia karyotype probably can be changed by intensive cytotoxic chemotherapy. Unfavorable prognosis, however, still persists in t(9;22) and t(4;11); "favorable" prognosis can be seen in t(8;21) and t(15;17). Inherited or induced chromosome instability is discussed as a possible predisposing factor for the origin of chromosome aberrations.
对792例急性淋巴细胞白血病（ALL）患儿和217例急性髓细胞白血病（AML）患者的白血病核型进行了分析。这些患者于1984年1月1日至1989年12月31日在德国多中心试验中进行登记并接受统一治疗。在不同的白血病亚组中发现了特定的染色体异常：如普通型ALL中超过50条染色体的超二倍体等数量畸变，或如B-ALL中的t(8;14)、T-ALL中的t(11;14)、前体B-ALL中的t(4;11)、前体B-ALL中的t(1;19)、AML-M3中的t(15;17)、AML-M2中的t(8;21)等结构畸变（易位）。白血病核型的预后意义可能会因强化细胞毒性化疗而改变。然而，t(9;22)和t(4;11)的预后仍然不良；t(8;21)和t(15;17)则可见“良好”预后。遗传或诱导的染色体不稳定性被认为是染色体畸变起源的一个可能的易感因素。
