Domschke S, Domschke W, Schmack B, Tympner F, Junge O, Wünsch E, Jaeger E, Demling L
Am J Dig Dis. 1976 Sep;21(9):789-92. doi: 10.1007/BF01073031.
Salivary, gastric, and pancreatic secretory responses to intravenous 13-norleucine-motilin (13-nle-motilin), a synthetic analog of motilin and biologically equivalent to the natural polypeptide, were studied in healthy volunteers. 13-nle-Motilin in doses of 100 ng/kg body wt/hr significantly stimulated gastric pepsin output, while H + secretion and serum gastrin levels remained unchanged. Enhanced pepsin secretion was not accompanied by an increase in gastric secretion of cyclic 3', 5'-adenosine monophosphate, nor did gastric mucosal levels of the cyclic nucleotide rise. A dose of 13-nle-motilin, which stimulated gastric pepsin output, did not exert any significant effect on salivary and pancreatic secretions.
在健康志愿者中研究了静脉注射13-去甲亮氨酸胃动素（13-nle-胃动素）（一种胃动素的合成类似物，生物学活性等同于天然多肽）后唾液、胃液和胰液的分泌反应。剂量为100 ng/kg体重/小时的13-nle-胃动素显著刺激胃液胃蛋白酶分泌，而氢离子分泌和血清胃泌素水平保持不变。胃蛋白酶分泌增强并未伴随环磷腺苷胃分泌增加，环核苷酸的胃黏膜水平也未升高。刺激胃液胃蛋白酶分泌的13-nle-胃动素剂量对唾液和胰液分泌未产生任何显著影响。
