生长抑素对清醒和麻醉猫的胃肠功能以及对离体猫胰腺作用的比较。

Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Albinus M, Blair E L, Case R M, Coy D H, Gomez-Pan A, Hirst B H, Reed J D, Schally A V, Shaw B, Smith P A, Smy J R

J Physiol. 1977 Jul;269(1):77-91. doi: 10.1113/jphysiol.1977.sp011893.

Somatostatin, 10 microgram kg-1 hr-1, inhibited gastric acid and pepsin secretion stimulated by pentagastrin, 8 microgram kg-1 hr-1, in conscious and anaesthetized cats with chronically implanted gastric fistulae. In the acutely surgically prepared anaesthetized cat, Somatostatin inhibited pepsin secretion but produced little inhibition of gastric acid secretion or mucosal blood flow. 2. Secretin stimulated pancreatic juice volume was not significantly reduced in acutely prepared anaesthetized cats, but there was a limited reduction of cholecystokinin-pancreozymin stimulated pancreatic amylase secretion and gall bladder contraction. 3. Somatostatin had neither stimulatory nor inhibitory effects on electrolyte and amylase secretion in the isolated saline-perfused cat pancreas. 4. The results suggest that some of the effects of Somatostatin may depend on the interaction on the target cell of other factors, nervous or humoral which may vary in different experimental preparations.

对于长期植入胃瘘的清醒和麻醉猫，10微克/千克·小时的生长抑素可抑制由8微克/千克·小时的五肽胃泌素刺激引起的胃酸和胃蛋白酶分泌。在急性手术制备的麻醉猫中，生长抑素抑制胃蛋白酶分泌，但对胃酸分泌或黏膜血流的抑制作用很小。2. 在急性制备的麻醉猫中，促胰液素刺激的胰液量没有显著减少，但胆囊收缩素-促胰酶素刺激的胰腺淀粉酶分泌和胆囊收缩有一定程度的减少。3. 生长抑素对离体盐水灌注的猫胰腺中的电解质和淀粉酶分泌既无刺激作用也无抑制作用。4. 结果表明，生长抑素的某些作用可能取决于其他因素（神经或体液因素）与靶细胞的相互作用，而这些因素在不同的实验制备中可能有所不同。

Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.